What Are MKO Melts?

MKO Melts are a type of oral sedative used in medical and aesthetic procedures to provide mild to moderate sedation. The name MKO stands for Midazolam, Ketamine, and Ondansetron, which are the three active ingredients in the medication. These dissolvable tablets (or "melts") are placed under the tongue (sublingual administration) for quick absorption into the bloodstream.

What Are MKO Melts Used For?

MKO Melts are commonly used to provide relaxation and anxiety relief during minimally invasive procedures, such as:
✅ Aesthetic treatments (e.g., Morpheus8, microneedling, laser resurfacing)
✅ Dental procedures
✅ Minor surgical or cosmetic procedures
✅ In-office medical treatments

What Are the Ingredients & Their Effects?

1. Midazolam (Benzodiazepine) – Provides anxiety relief, muscle relaxation, and mild sedation.

2. Ketamine (NMDA Receptor Antagonist) – Acts as a dissociative anesthetic, offering pain relief and deeper relaxation.

3. Ondansetron (Zofran, Anti-Nausea Drug) – Prevents nausea and vomiting, which can sometimes be a side effect of sedation.

Benefits of MKO Melts:

✔ Quick-acting and non-invasive (dissolves under the tongue)
✔ Reduces anxiety, discomfort, and pain during procedures
✔ Provides conscious sedation, meaning you remain awake but relaxed
✔ Minimal side effects compared to IV sedation or general anesthesia
✔ No needles required, making it ideal for those with needle anxiety

How Long Do MKO Melts Last?

• Onset: 10-20 minutes after dissolving under the tongue

• Duration: Effects last about 60-90 minutes, depending on dosage and individual response

• Recovery: Patients may feel drowsy for a few hours, so arranging a ride home is recommended after treatment

Possible Side Effects of MKO Melts:

🟡 Drowsiness or grogginess
🟡 Mild dizziness
🟡 Dry mouth
🟡 Temporary confusion or memory loss (common with midazolam)

Who Should Avoid MKO Melts?

🚫 Pregnant or breastfeeding women
🚫 Patients with severe respiratory issues
🚫 Those allergic to benzodiazepines, ketamine, or ondansetron

MKO Melts provide a safe and effective sedation option for those undergoing non-invasive aesthetic treatments or minor medical procedures. Always consult with a qualified provider to determine if this sedation method is right for you